Ahmed Al-Rubaei Nr3.ps
نویسنده
چکیده
......................................................................................................V SAMMANFATTNING ................................................................................... VII TABLE OF CONTENTS ................................................................................. IX LIST OF PAPERS............................................................................................ XI
منابع مشابه
Davood Khodadad Nr3.ps
................................................................................................................................................. iii Thesis...................................................................................................................................................... v Part I Background of the work .............................................................
متن کاملSubunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors.
N-Methyl-D-aspartate receptors (NMDARs) composed of NR1 and NR3 subunits differ from other NMDAR subtypes in that they require glycine alone for activation. However, little else is known about the activation mechanism of these receptors. Using NMDAR glycine-site agonists/antagonists in conjunction with functional mutagenesis of the NR1 and NR3 ligand-binding cores, we demonstrate quite surprisi...
متن کاملNew insights into the not-so-new NR3 subunits of N-methyl-D-aspartate receptor: localization, structure, and function.
The NR3 subunits (NR3A and NR3B) are new players in a well established field of N-methyl-d-aspartate (NMDA) receptors, previously involving the NR1 and NR2 subunits. Their incorporation into conventional NMDA receptors forms glutamate-activated NR1/NR2/NR3 triheteromers, whereas the omission of the glutamate-binding NR2 subunits results in excitatory glycine-activated NR1/NR3 diheteromers. Thes...
متن کاملNew insights into the not - so - new NR 3 subunits of NMDA receptor : Localization , structure and function
The NR3 subunits (NR3A and NR3B) are new players in a well-established field of N-methyl-D-aspartate (NMDA) receptor, previously involving the NR1 and NR2 subunits. Their incorporation into conventional NMDA receptors forms glutamate-activated NR1/NR2/NR3 triheteromers, while the omission of the glutamate-binding NR2 subunits results in excitatory glycine-activated NR1/NR3 diheteromers. These N...
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